Uterus transplantation: From animal models through the first heart beating pregnancy to the first human live birth

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ÖZKAN Ö., DOĞAN N. U., ÖZKAN Ö., Mendilcioglu İ. İ., DOGAN S., Aydınuraz B., ...Daha Fazla

WOMENS HEALTH, cilt.12, sa.4, ss.442-449, 2016 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 12 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1177/1745505716653849
  • Dergi Adı: WOMENS HEALTH
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.442-449
  • Anahtar Kelimeler: Absolute uterine factor infertility, deceased donor, infertility, uterus transplantation, NONHUMAN PRIMATE MODELS, UTERINE TRANSPLANTATION, CYNOMOLGUS-MACAQUES, MULTIORGAN DONOR, RAT UTERUS, AUTOTRANSPLANTATION, RETRIEVAL, TRIAL, ALLOTRANSPLANTATION, RECONSTRUCTION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Absolute uterine factor infertility affects 3-5% of the general population, and unfortunately this condition is untreatable. There are some available options, including surrogacy or adoption, but neither of these suits each and every woman who desires to have her own genetic child. With recent advances in surgery and transplant immunology, uterus transplantation may be a source of hope for these women with uterine infertility. In the last decade, a number of animal species including rats, mice, rabbits, pigs, sheep, and primates have been used as experimental models, and pregnancies were achieved in some of these. Human data consist of 11 subjects yielding positive pregnancy results with no live births in the second trial from Turkey and, more fortunately, live births from the latest trial from Sweden. In the light of all these studies, uterus transplantation has been proven to be a viable option for women with uterine factor infertility.