Evaluation of factors affecting tumor response and survival in patients with primary and metastatic liver cancer treated with microspheres

DEMIRELLI S., ERKILIÇ M., Oner A. O., BUDAK E. S., GUNDUZ S., ÖZGÜR Ö., ...Daha Fazla

NUCLEAR MEDICINE COMMUNICATIONS, cilt.36, sa.4, ss.340-349, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1097/mnm.0000000000000257
  • Dergi Adı: NUCLEAR MEDICINE COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.340-349
  • Anahtar Kelimeler: survival, technetium-99m macroaggregated albumin, tumor response, yttrium-90, UNRESECTABLE HEPATOCELLULAR-CARCINOMA, Y-90 GLASS MICROSPHERES, RADIOEMBOLIZATION, RADIATION, THERAPY, DOSIMETRY, SECONDARY, TRIAL, Y-90-MICROSPHERES, BRACHYTHERAPY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objective Radioembolization with the yttrium-90 (Y-90) microspheres is being used increasingly more often in the treatment of patients with primary or metastatic liver cancer. Although technetium-99m macroaggregated albumin (Tc-99m MAA) scintigraphy performed following diagnostic angiography has an important role in predicting the effectiveness of treatment and in dose estimation, the number of studies using quantitative assessment of Tc-99m MAA scintigraphy is limited in this field. In the present study, the aim was to assess whether a tumor dose is required to obtain objective tumor response and to check whether this threshold value is predictive in terms of tumor response, survival, and liver toxicity by using Tc-99m MAA single-photon emission computed tomography (SPECT) images.