The abelson tyrosine kinase (c-Abl) expression on the mouse uterus and placenta during gestational period

Yaba A., Kayisli U. A., Johnson J., Demir R., DEMİR N.

JOURNAL OF MOLECULAR HISTOLOGY, cilt.42, sa.2, ss.91-96, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s10735-011-9310-1
  • Dergi Adı: JOURNAL OF MOLECULAR HISTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.91-96
  • Anahtar Kelimeler: c-Abl, Mouse, Uterus, Decidua, Placentation, FAMILY KINASES, MICE, DIFFERENTIATION, PROTOONCOGENES, IMPLANTATION, ACTIN, FETAL
  • Akdeniz Üniversitesi Adresli: Evet

Özet

c-Abl is a protein tyrosine kinase which has very important roles in signal transduction, control of the cell cycle, cell motility, proliferation, and inhibition of apoptosis. We hypothesized that c-Abl may play an important role on uterine remodeling during pre-receptive, receptive and non-receptive endometrium. Our aim is to investigate the expression of c-Abl protein tyrosine kinase in uterine remodeling and placental development in mouse gestational stage. We performed c-Abl immunohistochemistry on mouse uterine tissue sections on days 1-9, 11, 13, and 15 of pregnancy. c-Abl was highly upregulated in the uterine luminal epithelium and other endometrial structures including glands and blood vessels in pre-receptive and receptive endometrium. Therefore these results demonstrate a role for c-Abl in uterine remodeling during decidualization, implantation, and placentation throughout gestation.