Characterizing gradient echo signal decays in gynecologic cancers at 3T using a Gaussian augmentation of the monoexponential (GAME) model

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ÇİRİŞ P., Balasubramanian M., Damato A. L., SEETHAMRAJU R. T., Tempany-Afdhal C. M., Mulkern R. V., ...Daha Fazla

JOURNAL OF MAGNETIC RESONANCE IMAGING, cilt.44, sa.4, ss.1020-1030, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1002/jmri.25226
  • Dergi Adı: JOURNAL OF MAGNETIC RESONANCE IMAGING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1020-1030
  • Anahtar Kelimeler: biophysical modeling, Lorentzian, Gaussian, transverse relaxation, blood oxygenation, gynecologic cancers, UTERINE CERVICAL-CANCER, TUMOR OXYGEN-TENSION, VASCULAR DENSITY, CELL-DENSITY, BOLD-MRI, 3.0 T, HYPOXIA, RELAXATION, RADIOTHERAPY, CARCINOMA
  • Akdeniz Üniversitesi Adresli: Evet

Özet

PurposeTo assess whether mapping with a standard Monoexponential (ME) or a Gaussian Augmentation of the Monoexponential (GAME) decay model better characterizes gradient-echo signal decays in gynecological cancers after external beam radiation therapy at 3T, and evaluate implications of modeling for noninvasive identification of intratumoral hypoxia. Materials and Methods: Multi-gradient-echo signals were acquired on 25 consecutive patients with gynecologic cancers and three healthy participants during inhalation of different oxygen concentrations at 3T. Data were fitted with both ME and GAME models. Models were compared using F-tests in tumors and muscles in patients, muscles, cervix, and uterus in healthy participants, and across oxygenation levels.