Mass spectrometric quantification of urinary human liver fatty acid binding protein in renal transplant recipients.

Ozcan F., Akbas H., Kırac E., Suleymanlar G., Aslan M., Yucel G.

Rapid communications in mass spectrometry : RCM, cilt.30, ss.603-10, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1002/rcm.7474
  • Dergi Adı: Rapid communications in mass spectrometry : RCM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.603-10
  • Akdeniz Üniversitesi Adresli: Evet

Özet

RationaleUrinary liver fatty acid binding protein (L-FABP) has been evaluated as a promising early biomarker of renal ischemia in human kidney transplant patients. The use of L-FABP in clinical practice requires that this biomarker be associated with an analytical method that combines specificity, accuracy and robustness. This study aimed to evaluate an optimized multiple reaction monitoring (MRM) method using ultrafast liquid chromatography coupled with tandem mass spectrometry to measure urinary L-FABP levels in renal transplant recipients.