Noninvasive Assessment of Atherosclerosis in Patients with Isolated Hypertension


Guntekin U., Gunes Y., Gunes A., Ceylan Y., Gumrukcuoglu H. A., Yucel Y., ...Daha Fazla

ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, cilt.27, sa.2, ss.155-160, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1111/j.1540-8175.2009.00987.x
  • Dergi Adı: ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.155-160
  • Anahtar Kelimeler: hypertension, flow-mediated dilatation, intima-media thickness, propagation velocity, INTIMA-MEDIA THICKNESS, CAROTID-ARTERY INTIMA, BRACHIAL-ARTERY, ENDOTHELIAL DYSFUNCTION, AORTIC STIFFNESS, RISK-FACTORS, DILATION, GUIDELINES, CHILDREN, DISEASE
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

Background: Endothelial dysfunction is considered the first stage in the development of atherosclerosis. Brachial artery flow-mediated dilatation (FMD) has been used to assess endothelial dysfunction. An impaired FMD response may reflect a vascular phenotype prone to atherosclerosis. The thickness of the common carotid intima-media (CIMT) as measured by ultrasound represents a marker of structural atherosclerosis. Recently, it has been shown that color M-mode propagation velocity measured along the origin of descending thoracic aorta (AVP) may reflect atherosclerosis. In this study, the effects of isolated hypertension on these atherosclerosis markers are investigated. Methods: Fifty patients with newly diagnosed hypertension and forty healthy people were enrolled. Patients were evaluated with transthoracic echocardiography. Diastolic functions were evaluated by transmitral filling parameters of deceleration time (DT), E/A ratio, and isovolumetric relaxation time (IVRT). Carotid intima-media thickness, FMD, and AVP were measured. Results: Age, gender, and BMI of both groups were similar. Compared to control group CIMT, DT and IVRT values were significantly higher, and FMD and AVP values were significantly lower in hypertensive patients. There were significant correlations between AVP and CIMT (r = -0.699, P < 0.001), AVP and FMD (r = 0.400, P < 0.001), and FMD and CIMT (r = -0.600, P < 0.001). Carotid intima-media thickness, AVP, and FMD were significantly correlated with systolic and diastolic blood pressures and DT and IVRT. Conclusions: In patients with isolated hypertension, AVP and FMD decrease and CIMT increases. In addition, CIMT is inversely correlated with AVP and FMD, and AVP is directly correlated with FMD. (ECHOCARDIOGRAPHY 2010;27:155-160).