Secretomes reveal several novel proteins as well as TGF-beta 1 as the top upstream regulator of metastatic process in breast cancer

ERİN N., OĞAN N., YERLİKAYA A.

BREAST CANCER RESEARCH AND TREATMENT, cilt.170, sa.2, ss.235-250, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 170 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s10549-018-4752-8
  • Dergi Adı: BREAST CANCER RESEARCH AND TREATMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.235-250
  • Anahtar Kelimeler: Breast cancer, Proteomic, Fibulin-4, BMP-1, MMP, TGF-beta 1, Liver metastasis, Brain metastasis, MATRIX METALLOPROTEINASES MMP-2, THYMIC STROMAL LYMPHOPOIETIN, SENSORY NEURONS PROMOTES, GROWTH-FACTOR-BETA, GENE-EXPRESSION, N-CADHERIN, ANNEXIN A1, TGF-BETA, MESENCHYMAL TRANSITION, COLORECTAL-CANCER
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Metastatic breast cancer is resistant to many conventional treatments and novel therapeutic targets are needed. We previously isolated subsets of 4T1 murine breast cancer cells which metastasized to liver (4TLM), brain (4TBM), and heart (4THM). Among these cells, 4TLM is the most aggressive one, demonstrating mesenchymal phenotype. Here we compared secreted proteins from 4TLM, 4TBM, and 4THM cells and compared with that of hardly metastatic 67NR cells to detect differentially secreted factors involved in organ-specific metastasis.