Heterotopic ossification related to toxic epidermal necrolysis in a patient with Behcet's disease

Samanci N., Balci N., Alpsoy E.

JOURNAL OF DERMATOLOGY, cilt.32, sa.6, ss.469-473, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 6
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1111/j.1346-8138.2005.tb00782.x
  • Dergi Adı: JOURNAL OF DERMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.469-473
  • Anahtar Kelimeler: Behcet's disease, toxic epidermal necrolysis, heterotopic ossification, case report, STEVENS-JOHNSON-SYNDROME, ERYTHEMA MULTIFORME
  • Akdeniz Üniversitesi Adresli: Evet

Özet

We describe a 44-year-old woman with an 18-year-history of Behcet's disease (BD) in whom heterotopic ossification (HO) developed as a complication of toxic epidermal necrolysis (TEN). The patient presented with high fever, a progressive erythematous rash including target-like lesions, flaccid blister formations, and severe detachment. The patient was diagnosed with TEN, and methylprednisolone therapy was started. In the 2nd month of her hospital course, painful limitation developed in both her elbow and shoulder joints. Laboratory and radiographic findings confirmed HO of these areas. BD associated with TEN and HO is a previously unreported entity. In such a condition, determination of underlying genetic abnormality is important. Additionally, HO should be considered as a potential cause of the symptoms related to the joints.