Existence of acute lymphoblastic leukemia and osteosarcoma in a child

Karauzum S., Hazar V., Acikbas I., Gelen T., Yesilipek M., Luleci G.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.24, sa.7, ss.572-574, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 7
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1097/00043426-200210000-00017
  • Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.572-574
  • Anahtar Kelimeler: acute lymphoblastic leukemia, osteosarcoma, second malignant neoplasm, NEOPLASMS, GENE, MALIGNANCY, TUMORS, RB
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The existence of acute lymphoblastic leukemia (ALL) and osteosarcoma is described. An 8-year-old girl had osteosarcoma diagnosed on radiologic and pathologic examination during ALL maintenance treatment. Cytogenetic analyses in primary cell culture of osteosarcoma tissue from the patient showed complex chromosomal abnormalities including t(1; 19), usually seen in B precursor cell ALL, and del 13, found in a great majority of primary osteosarcomas. To show the possibility of the existence of the genetic susceptibility caused by RB gene rearrangements, we used molecular technique. But we could not determine any association between RB gene and genetic susceptibility.