Impairment of GABA-mediated contractions of rat isolated ileum by experimental diabetes

Ozdem S. S., SADAN G.

PHARMACOLOGY, cilt.59, sa.3, ss.165-170, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 3
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1159/000028317
  • Dergi Adı: PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.165-170
  • Anahtar Kelimeler: gamma-aminobutyric acid, experimental diabetes, ileum, GUINEA-PIG ILEUM, GAMMA-AMINOBUTYRIC-ACID, MYENTERIC PLEXUS, CHOLINERGIC TRANSMISSION, SMOOTH-MUSCLE, NITRIC-OXIDE, LONGITUDINAL MUSCLE, SMALL-INTESTINE, SUBSTANCE-P, NEURONS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The effect of diabetes induced by pretreatment with streptozotocin 6 weeks prior to the study on the responses induced by gamma-aminobutyric acid (GABA), the GABA(A) agonist 3-aminopropane sulfonic acid (3-APS), and acetylcholine in the rat isolated ileum was evaluated. GABA, 3-APS, and acetylcholine showed a rightward shift in their concentration-dependent effects in the ileum that also attained a lower maximum in streptozotocin-diabetic rats as compared with control rats (p < 0.05). It is suggested that the reduced contractile responses of ileal smooth muscle to GABA and 3-APS might be due to a direct effect of diabetes on the GABAergic system or to its effect on the cholinergic system.