Are innate lymphoid cells friend or foe in human pregnancy?

Katirci E., Kendirci-Katirci R., KORGUN E. T.

American Journal of Reproductive Immunology, cilt.91, sa.3, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 91 Sayı: 3
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1111/aji.13834
  • Dergi Adı: American Journal of Reproductive Immunology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: adaptive immunity, cytokines, innate immunity, innate lymphoid cells, pregnancy, transcription factors
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Innate lymphoid cells (ILCs) are involved in the innate immune system because they lack specific antigen receptors and lineage markers. ILCs also display phenotypic and characteristic features of adaptive immune cells. Therefore, ILCs are functional in essential interactions between adaptive and innate immunity. ILCs are found in both lymphoid and nonlymphoid tissues and migrate to the area of inflammation during the inflammatory process. ILCs respond to pathogens by producing a variety of cytokines and are involved in the barrier defense of antigens and in many immunological processes such as allergic events. Recent research has shown that ILCs are functional during human pregnancy and have been suggested to be essential for the healthy progression of pregnancy. In this review, we focus on the role of ILCs in human pregnancy by discussing the relationship between ILCs and the pregnancy microenvironment, specifically summarizing the role of ILCs in physiological and pathological pregnancies.